Lauren O. Bakaletz Ph.D.

The Research Institute at Nationwide Children's Hospital

Lauren O. Bakaletz, Ph.D. is Director of the Center for Microbial Pathogenesis, Vice President of Basic Sciences and holds the Tillie E. Coleman Endowed Chair in Pediatric Research at The Research Institute at Nationwide Children's Hospital. She is a Professor in the Departments of Pediatrics and Otolaryngology within the College of Medicine at the Ohio State University, where she was recently named a Distinguished Professor. Dr. Bakaletz has served on multiple advisory, review, and editorial boards and is listed as inventor on 26 U.S. patents. During her professional career, she has contributed nearly 160 original articles, reviews and book chapters, and has presented over 300 papers at national and international meetings and symposia. The Bakaletz lab studies the molecular mechanisms that underlie polymicrobial infections of the respiratory tract, including otitis media (OM), sinusitis, exacerbations of COPD and CF. As an outcome of this work, the lab is actively involved in the identification, design and testing of novel vaccine candidates for prevention and/or resolution of otitis media due to nontypeable Haemophilus influenzae, a bacterium which causes acute OM as well as being the predominant pathogen of chronic and recurrent OM. In addition to traditional parenteral vaccines, the lab has been developing a method to effectively immunize against OM non-invasively, by placement of a 'band-aid' onto the skin just behind the ear. Since bacterial biofilms contribute significantly to the chronicity and/or recurrence of many diseases, the lab is also interested in characterizing the proteome of bacterial biofilms in an attempt to identify potential targets for either therapeutic intervention or biofilm disruption.