John Engelhardt Ph.D.


John F. Engelhardt is the Director of the Center for Gene Therapy, Professor and Head of the Department of Anatomy and Cell Biology at the University of Iowa Roy J. and Lucille A. Carver College of Medicine. He currently holds the Roy J. Carver Chair in Molecular Medicine and is Director of the P30 Center for Gene Therapy of Cystic Fibrosis. He received his undergraduate degree in biochemistry from Iowa State University in 1985, and his doctorate in human genetics from Johns Hopkins University in 1990. Research in the Engelhardt laboratory focuses on the molecular basis of cystic fibrosis disease pathologies, and on the development of gene therapies for this disorder. Included are four major research areas include the study of: 1) lung molecular and cellular biology as it relates to the pathogenesis and treatment of cystic fibrosis (CF) lung disease, 2) the development of viral vector for gene therapy and gene editing, 3) pathogenesis cystic fibrosis related diabetes, and 4) the study of airway stem cell niches, the regulatory mechanisms that control stem cell proliferation and repair in the airway, and the development of cell-based therapies for CF using stem cells.