Lucas Hoffman M.D., Ph.D.

Associate Professor

Luke is Associate Professor of Pediatrics and Microbiology at the University of Washington, Seattle, and Seattle Children's Hospital. He is a physician-scientist particularly interested in understanding the microbial determinants of clinical outcomes in children with cystic fibrosis (CF). Clinically, Luke is a pediatric pulmonologist who cares for children with CF and other chronic lung diseases. As a microbiologist, Luke has worked in CF microbiology since 2002. He directs the SCH CF clinical microbiology laboratory, and he is the director of a National Resource Center supported by the Cystic Fibrosis Foundation Therapeutic Development Network (CF-TDN) dedicated to providing consultation and services regarding CF microbiological diagnosis and testing-the Center for CF Microbiology (CCFM). Due to our growing appreciation over the past decade that CF respiratory infections are frequently polymicrobial, particularly in children, Luke's research laboratory makes extensive use of whole-genome and microbiome sequencing methods to analyze the microbes in CF specimens, both fecal and respiratory, and relate microbial and clinical characteristics to generate new pathophysiological models to test subsequently with both bench and bedside approaches. One of the Hoffman lab's primary research focuses for the past five years has been on using refined, advanced microbiology methods, including sensitive culture methods, next-generation culture techniques and microbiome methods.