Jean P. Molleston M.D.

Section Chief

I am a pediatric clinical researcher and Director of the Section of Pediatric Gastroenterology, Hepatology, and Nutrition at Indiana University School of Medicine. I have over 20 years of experience managing and studying children with gastrointestinal and liver diseases as well as CF. I have participated in U01 multicenter research networks studying fatty liver in children (NASH CRN), cholestatic liver diseases of children (CHILDREN), cystic fibrosis-related liver disease (CFLD), drug-induced liver injury (DILIN) and hepatitis C in children (Peds C). In the CFLD research network, ours was one of the top 3 recruiting centers, resulting in a Journal of Pediatrics publication on baseline liver ultrasound data on children with CF and in ongoing carefully designed studies to longitudinally investigate ultrasound, MRE and (soon) transient elastography to identify and follow CF liver disease. I led a writing group performing a retrospective analysis of variceal bleeding and adverse liver outcomes in CFF registry patients with CF-related cirrhosis; we are also designing a prospective nested study within the CF registry to gather quality longitudinal clinical data on patients with CF cirrhosis. I have had long-term involvement with the CF foundation, and have mentored Dr Molly Bozic in several roles, initially as a CF fellow, then as a DIGEST grantee and CFF TDN clinical trials co-PI; we are studying CF medical education as well as surveying gastrointestinal symptoms in CF clinic. We have developed a robust CF/GI clinic with effective collaborations.