David Bedwell Ph.D.

Professor & Chairman

I received a PhD in Molecular Biology at the University of Wisconsin-Madison in 1985. After postdoctoral training at the California Institute of Technology, I accepted a faculty position at the University of Alabama at Birmingham (UAB) in 1988. After progressing through the faculty ranks, I was appointed Chair of the Department of Biochemistry and Molecular Genetics at UAB in 2016. My lab seeks to understand the mechanistic details of translation termination in eukaryotes, and to use that knowledge to develop therapeutic strategies to suppress nonsense mutations that are associated with a broad range of genetic diseases. In addition, other important cellular processes also intersect with the process of translation termination. For example, conserved cellular machineries also regulate the abundance of mRNAs based on the location of stop codons through the process of Nonsense-Mediated mRNA Decay (NMD). We are using a combination of genetics, biochemistry, and cell biology to better understand the molecular details of these processes.