Luis Galietta Ph.D.

I am a senior investigator in the Gaslini Institute, one of the largest pediatric hospital and research centers in Europe. I have several years of experience in research on cystic fibrosis and molecular mechanisms underlying anion transport in epithelial cells. My major achievements are: identification of correctors and potentiators of the mutant CFTR protein, characterization of ion transport mechanisms in airway epithelial cells, identification of TMEM16A protein as the major contributor to calcium-dependent chloride secretion in bronchial epithelial cells, development of methods for the high-throughput screening of small molecule and siRNA libraries, development of protocols for the generation of highly differentiated bronchial epithelial cell cultures. In the last years, my research has been particularly focused on the identification of small molecule correctors for the ∆F508 mutation in cystic fibrosis. In parallel, I have also worked at the identification of strategies to pharmacologically stimulate the TMEM16A channel as an alternative target in cystic fibrosis. Positions and employment 1985-1990: Post-doctoral research fellow, Gaslini Institute and Institute of Biophysics, Genova, ITALY 1991-1995: Investigator, Lab. of Molecular Genetics, Gaslini Institute, Genova, ITALY 1996-present: Senior Investigator/Group Leader, Lab. of Molecular Genetics, Gaslini Institute, Genova, ITALY 2000-2001: Visiting Scientist, University of California San Francisco 2012-present: Appointment as Professor in Molecular Genetics, University of Genova