Changhong Li M.D., Ph.D.

Dr. Changhong Li is trained as an Endocrinologist and islet biologist. In the past 16 years, he has mainly researched the regulation of fuel metabolism in pancreatic islets and insulin/glucagon secretion in congenital hyperinsulinism (HI), a group of disorders that causes hypoglycemia in infants and children. His work has involved characterizing most of the known disease models of HI, including glutamate dehydrogenase transgenic mice, sulfonylurea receptor 1 knockout mice, short-chain 3-hydroxy fatty acyl-CoA dehydrogenase knockout mice, and glucokinase transgenic mice. He also intensively use human islets as models to study insulin secretion and beta-alpha cell communication in normal as well as diabetic human islets. As PI or co-PI for several university-, industry- and NIH-funded projects, he has established a strong foundation for exam islet function in various disease models, including those with islets isolated from patients who have undergone pancreatectomy. In addition, he has successfully collaborated with other investigators for projects related to islet function. Those collaborations are fruitful, as evidenced by several peer-reviewed publications from each project. About 3 years ago, he started to work on CF-related diabetes. He and his collaborators have created a beta-cell specific CFTR knockout mouse model. They have already started to characterize the islet phenotype of this mouse model: the islet phenotype shares similarities with our HI mouse models. He obtained his MD and PhD in 1996 from Beijing Medical University, CHINA. He did his post-doc training in University of Tours, FRANCE as wells as Children's Hospital of Philadelphia. In year of 2010, he took faculty position as research assistant professor at department of pediatrics at Children's Hospital of Philadelphia & Perelman School of Medicine, University of Pennsylvania.